Publications by authors named "N F G C de Sousa"
The nucleus accumbens (NAc) is a key brain region for motivated behaviors, yet how distinct neuronal populations encode appetitive or aversive stimuli remains undetermined. Using microendoscopic calcium imaging in mice, we tracked NAc shell D1- or D2-medium spiny neurons' (MSNs) activity during exposure to stimuli of opposing valence and associative learning. Despite drift in individual neurons' coding, both D1- and D2-population activity was sufficient to discriminate opposing valence unconditioned stimuli, but not predictive cues.
View Article and Find Full Text PDFHaemorrhagic Shock in a Pregnant Patient and the Unsuspicious Subclavian Catheter.
Eur J Case Rep Intern Med
November 2024
Introduction: Central venous catheterisation (CVC) is a commonly performed procedure in clinical practice. Although usually safe, complications can arise such inadvertent vascular lesion. This report is of a case of left brachiocephalic vascular lesion due to a subclavian catheter, thus raising awareness about this potential complication, which is not always immediately recognised.
View Article and Find Full Text PDFArticle Synopsis
- - Catecholamine-secreting tumors (CSTs) are rare but can pose serious risks for both mother and baby during pregnancy, often complicating diagnosis due to similarities with conditions like preeclampsia.
- - A case study of a 24-year-old pregnant woman revealed that timely management of hypertension and surgical intervention were crucial; she was diagnosed with a CST at 27 weeks, managed with medication, and had an elective cesarean at 32 weeks, delivering a healthy baby.
- - Successful outcomes depend on early diagnosis, tailored medical and surgical approaches, and teamwork among various healthcare specialists, emphasizing the need for heightened awareness of CSTs in hypertensive pregnant patients.
Objective: To verify the temporal trend of neonatal mortality in the health regions of Pernambuco between 2000 and 2020.
Method: A time-series ecological study was conducted, analyzing the total neonatal mortality rate and its early and late components. For regression analysis, Joinpoint Regression was applied, trends were classified, and annual and average percentage changes were calculated for the period, with a significance level of 95%.
Colorectal cancer remains a significant cause of mortality worldwide. A spiro-acridine derivative, ()-1'-((4-bromobenzylidene)amino)-5'-oxo-1',5'-dihydro-10-spiro[acridine-9,2'-pyrrole]-4'-carbonitrile (AMTAC-19), showed significant cytotoxicity in HCT-116 colorectal carcinoma cells (half maximal inhibitory concentration, IC50 = 10.35 ± 1.
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