Publications by authors named "N F Fletcher"
Purpose: Receptor CUB-domain containing- protein 1 (CDCP1) was evaluated as a target for detection and treatment of breast cancer.
Experimental Design: CDCP1 expression was assessed immunohistochemically in tumors from 423 patients (119 triple-negative breast cancer (TNBC); 75 HER2+; 229 ER+/HER2- including 228 primary tumors, 229 lymph node and 47 distant metastases). Cell cytotoxicity induced in vitro by a CDCP1-targeting antibody-drug conjugate (ADC), consisting of the human/mouse chimeric antibody ch10D7 and the microtubule disruptor monomethyl auristatin E (MMAE), was quantified, including in combination with HER2-targeting ADC T-DM1.
Immune-modulating peptides have shown potential as novel immune-stimulating agents which enhance the secretion of anticancer cytokines in vitro. However, fast clearance from blood hampers the ability of such peptides to accumulate in the tumour and results in limited therapeutic efficacy in animal studies. To address the fast blood clearance, this work reports the development and validation of a novel polymeric nanoparticle delivery system for the efficient localization of an immunomodulating peptide in the tumour microenvironment (TME).
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- The study aimed to analyze how changes in upper lumbar lordosis after spinal fusion affect the alignment of unfused lower lumbar segments in patients with Adolescent Idiopathic Scoliosis.
- A retrospective review was conducted on 158 patients who underwent posterior spinal fusion, focusing on various spinal measurements and using MATLAB for 3D calculations.
- Results indicated that increased upper lumbar lordosis influenced the lordotic shape of distal unfused segments, with varying impacts based on the specific levels of fusion, while overall sagittal alignment remained stable.
Article Synopsis
- The study examines the impact of implant density on outcomes in posterior spinal fusion surgery for adolescent idiopathic scoliosis (AIS), revealing limited differences between high-density and moderate-density screw constructs.
- A total of 1865 patients were analyzed, showing similar age, sex distribution, and radiographic results, with slight advantages for high-density constructs in curve correction.
- Overall, the findings suggest that moderate-density constructs can be effectively used in routine AIS surgeries, as both densities resulted in comparable patient-reported and radiographic outcomes after two years.