Publications by authors named "N F Bashirova"
Article Synopsis
- T-2 toxin, a highly toxic trichothecene mycotoxin, was studied using high-resolution magic-angle spinning nuclear magnetic resonance (HRMAS NMR) and zebrafish embryos to explore its toxicity mechanisms.
- The study found that T-2 exposure resulted in lethality at around 105 ppb and influenced the production of reactive oxygen species (ROS), causing varied ROS levels in different organs.
- Metabolic profiling indicated significant disturbances in detoxification processes, membrane phospholipids, mitochondrial energy metabolism, and glucose metabolism, leading to a comprehensive understanding of T-2 toxicity for health implications.
Article Synopsis
- Polyethylene terephthalate (PET) is a widely used plastic, but its microplastics (MPs/NPs) pose increasing environmental threats that lack effective study methods.
- This study introduces a new approach using functionalized superparamagnetic iron oxide nanoparticles (PET-fSPIONs) and magnetic resonance microimaging (µMRI) to track PET NP distribution in germinating wheat seeds.
- Findings indicate significant accumulation of PET-fSPIONs in key seed areas and show effects on MRI relaxation times and lipid content, highlighting the method's ability to non-invasively monitor PET NP interactions in plant biology.
Known for their high stability and surfactant properties, per- and polyfluoroalkyl substances (PFAS) have been widely used in a range of manufactured products. Despite being largely phased out due to concerns regarding their persistence, bioaccumulation, and toxicity, legacy PFAS such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid continue to persist at high levels in the environment, posing risks to aquatic organisms. We used high-resolution magic angle spinning nuclear magnetic resonance spectroscopy in intact zebrafish (Danio rerio) embryos to investigate the metabolic pathways altered by PFOS both before and after hatching (i.
View Article and Find Full Text PDFZearalenone (ZEA) is a mycotoxin, commonly found in agricultural products, linked to adverse health impacts in humans and livestock. However, less is known regarding effects on fish as both ecological receptors and economically relevant "receptors" through contamination of aquaculture feeds. In the present study, a metabolomics approach utilizing high-resolution magic angle spinning nuclear magnetic resonance (HRMAS NMR) was applied to intact embryos of zebrafish (), and two marine fish species, olive flounder () and yellowtail snapper (), to investigate the biochemical pathways altered by ZEA exposure.
View Article and Find Full Text PDFPlastic pollution, especially by nanoplastics (NPs), has become an emerging topic due to the widespread existence and accumulation in the environment. The research on bioaccumulation and toxicity mechanism of NPs from polyethylene terephthalate (PET), which is widely used for packaging material, have been poorly investigated. Herein, we report the first use of high-resolution magic-angle spinning (HRMAS) NMR based metabolomics in combination with toxicity assay and behavioural end points to get systems-level understanding of toxicity mechanism of PET NPs in intact zebrafish embryos.
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