Mangiferin mitigates methotrexate-induced liver injury and suppresses hepatic stellate cells activation in rats: imperative role of Nrf2/NF-κB/NLRP3 signaling axis.

Ethnopharmacological Relevance: Mangifera indica (family Anacardiaceae), often acknowledged as mango and renowned for being a plant of diverse ethnopharmacological background since ancient times, harbors the polyphenolic bioactive constituent, mangiferin (MNG). MNG is a major phytochemical of Mangifera indica and other plants with a wide range of reported pharmacological activities, including antioxidant, anti-inflammatory, neuroprotective and hepatoprotective effects. MNG has also been utilized in traditional medicine; it is reportedly a major bioactive element in over 40 polyherbal products in traditional Chinese medicine (TCM), and two prominent anti-inflammatory, immunomodulatory and antiviral Cuban formulations.

Artificial intelligent fuzzy control and LAPO algorithm for enhancement LVRT and power quality of grid connected PV/wind hybrid systems.

Low Voltage Ride Through (LVRT) is considered one of the main and serious problems facing the electrical grid. It occurs due to three-phase symmetric faults and asymmetric faults such as a double line to ground fault that applies in this system. This paper applies Static Synchronous Compensators (STATCOM) to improve the LVRT capability and dynamic performance of an electrical grid linked to a Photovoltaic (PV)/Wind hybrid system through grid disturbances.

Alogliptin attenuates STZ-induced diabetic nephropathy in rats through the modulation of autophagy, apoptosis, and inflammation pathways: Targeting NF-κB and AMPK/mTOR pathway.

Aim: Diabetic nephropathy (DN) is a type of microvascular complication that arises from diabetes mellitus and leads to further health issues. Most importantly, the prevalence of DN is steadily rising in developed countries. This research explored the therapeutic benefits of alogliptin, a dipeptidyl peptidase IV (DPP-4) inhibitor, on streptozotocin (STZ)-induced DN and its underlying mechanisms in rats.

Renoprotective effect of berberine in cisplatin-induced acute kidney injury: Role of Klotho and the AMPK/mtor/ULK1/Beclin-1 pathway.

Cisplatin (Cisp) is a potent cancer drug, but its use is limited by acute kidney injury (AKI). Autophagy, a process that removes damaged proteins and maintains cellular homeostasis, has been shown to alleviate Cisp-induced AKI. The balance between autophagy and apoptosis is crucial to kidney protection.

Counting on AR: EEG responses to incongruent information with real-world context.

Augmented Reality (AR) technologies enhance the real world by integrating contextual digital information about physical entities. However, inconsistencies between physical reality and digital augmentations, which may arise from errors in the visualized information or the user's mental context, can considerably impact user experience. This work characterizes the brain dynamics associated with processing incongruent information within an AR environment.