Publications by authors named "N Ejiri"
Article Synopsis
- - Atopic dermatitis (AD) is a chronic skin condition characterized by itching and is influenced primarily by type 2 inflammation, although the role of non-type 2 inflammation is not fully understood.
- - Researchers developed the FADS mouse model to study AD, finding that disrupting or inhibiting periostin, a molecule involved in type 2 inflammation, reduces eczema symptoms and inflammation without affecting type 2 inflammation levels.
- - The study suggests that periostin connects inflammation's effects on skin cells to the sensation of itching, making it a potential target for new treatments for atopic dermatitis.
The FADS mouse: A novel mouse model of atopic keratoconjunctivitis.
J Allergy Clin Immunol
December 2021
Article Synopsis
- The study introduces a new mouse model named FADS (facial AD with scratching), which develops symptoms similar to atopic keratoconjunctivitis (AKC) due to the deletion of the Ikk2 gene in skin fibroblasts.
- Researchers evaluated the ocular lesions in FADS mice to see if they resembled human AKC, and measured a biomarker called tear periostin to assess treatment efficacy.
- The findings showed that FADS mice had significant eye issues and that the medication betamethasone was more effective than tacrolimus in reducing corneal damage and affecting tear periostin levels, highlighting the model's potential for testing AKC treatments.
Background: Although the pathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear, there are little evidences of the pathogenesis in patients with thoracolumbar/lumbar AIS. The purpose of this study was to identify proteins or proteomes that may be causally related to the pathogenesis of AIS with structured thoracolumbar/lumbar curvature using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE).
Methods: A total of 20 control volunteers and 61 AIS in patients with thoracolumbar/lumbar curvature were included.
Atopic dermatitis is a chronic inflammatory skin disease with persistent pruritus. To clarify its molecular mechanism, it is important to establish a mouse model similar to the phenotypes of atopic dermatitis patients, particularly in exhibiting scratching behavior. Ikk2, a component of the IκB kinase complex, exerts pro-inflammatory responses, whereas its deficiency in keratinocytes paradoxically causes skin inflammation.
View Article and Find Full Text PDFStereoscopic images of breast tumors using 3D real-time tissue elastography.
J Med Ultrason (2001)
July 2015
Purpose: This study aimed at evaluating the usefulness of 3D real-time tissue elastography (RTE) images for diagnosing breast tumors.
Methods: A total of 166 breast tumor patients who underwent conventional ultrasound and 2D and 3D RTE examinations were retrospectively analyzed. The 3D RTE images were divided into three types according to the occupancy of blue contrast images.