Publications by authors named "N Eikelis"
Background: The incidence of silicosis has increased due to occupational silica exposure from artificial stone, with no treatments proven to halt or reverse the disease. Whole lung lavage (WLL) involves the instillation of fluid into the lungs to wash out silica particles and disease-causing inflammatory cells. This study aimed to determine the feasibility, safety, and possible benefit of WLL in patients with artificial stone silicosis.
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- Two cystic fibrosis rat models were studied to assess lung function, revealing that although they had CFTR mRNA reductions, they did not show typical signs of CF lung disease.
- Using advanced imaging techniques, the study measured how localized physical obstructions affected lung ventilation and found increased ventilation issues in CF rats compared to healthy controls.
- The findings highlighted that CF rats exhibit altered respiratory mechanics, necessitating more effort to breathe due to stiffer lungs, and demonstrated the effectiveness of XV imaging for assessing lung ventilation.
Loneliness is recognised as a risk factor for cardiovascular disease development. However, it is unclear whether loneliness itself or other closely related mental health symptoms, such as depression and social anxiety, are associated with the development of cardiovascular disease. In the present study, we examined the relationship between loneliness and several early cardiovascular disease markers in young adults, after controlling for depression and social anxiety.
View Article and Find Full Text PDFis the most common cystic fibrosis transmembrane conductance regulator (CFTR) gene variant that results in the recessive genetic disorder cystic fibrosis (CF). The recent development of highly effective CFTR modulator therapies has led to significant health improvements in individuals with this mutation. While numerous animal models of CF exist, few have a CFTR mutation that is amenable to the triple combination therapy elexacaftor-tezacaftor-ivacaftor (ETI).
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