Publications by authors named "N Edvardsson"
The association of socioeconomic status with cardiovascular morbidity and mortality is well known, but data on the influence of education level on mortality in individuals with atrial fibrillation (AF) are scarce. We investigated education level as a predictor of all-cause mortality in patients diagnosed with AF. This retrospective cohort study used a database created from several Swedish nationwide registries to identify all patients hospitalized with a diagnosis of AF hospitalized from 1995 to 2008.
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- Existing antiarrhythmic drugs have limitations, and a new drug called AP30663, which targets K2 channels, showed promise in animal studies for treating atrial fibrillation (AF), but its effectiveness in humans was not yet known.
- A phase 2 trial was conducted with patients experiencing AF for 7 days or less, comparing two doses of AP30663 to a placebo, but the trial had to be halted due to slow enrollment during the COVID-19 pandemic.
- Results indicated that both doses of AP30663 led to a significant percentage of patients achieving cardioversion from AF to normal sinus rhythm within 90 minutes, with no serious adverse events linked to the drug, suggesting it could be a potential treatment
Aims: AP30663 is a novel compound under development for pharmacological conversion of atrial fibrillation by targeting the small conductance Ca activated K (K2) channel. The aim of this extension phase 1 study was to test AP30663 at higher single doses compared to the first-in-human trial.
Methods: Sixteen healthy male volunteers were randomized into 2 cohorts: 6- and 8-mg/kg intravenous single-dose administration of AP30663 vs.
Background: The incidence of atrial fibrillation (AF) has long been increasing, and AF is associated with increased mortality. Over time, mortality trends may differ between subgroups depending on their underlying risk patterns and treatments.
Aim: To explore all-cause-mortality trends over time in patients hospitalized for incident AF, and the effects of age, stroke risk, and education level.
Background: Atrial fibrillation (AF) is common after coronary artery bypass graft (CABG) surgery.
Objective: To evaluate the incidence and recurrence rate of AF during 1 year after CABG surgery. We also aimed at calculating the AF burden and compare long-term intermittent vs continuous electrocardiogram (ECG) monitoring.