Albumin-collodion activated charcoal hemoperfusion in the treatment of severe theophylline intoxication in a 3-year-old patient.

During treatment for asthma, a 3-year-old, 15-kg child was given 750 mg of theophylline in error. Within three hours she was treated with albumin-collodion activated charcoal (ACAC) hemoperfusion. Immediately before treatment her serum theophylline level was 74 microgram/ml.

NADPH-dependent lipid peroxidation and its effects on aminopyrine N-demethylation in subcellular fractions of human neonatal liver.

NADPH-dependent lipid peroxidation was determined in humans, using subcellular fractions of livers obtained from newborn infants. As reported for other species, activity was concentrated in the microsomal fraction and was similar to that found in the rat. High activity of lipid peroxidation induced by iron decreased aminopyrine N-demethylation and slightly reduced linearity time for the reaction.