Effect of combined low dose praziquantel and oxamniquine on different stages of schistosome maturity.

Combined low doses of praziquantel and oxamniquine were tested against different stages of Schistosoma mansoni in infected Swiss albino mice. The effect of combination therapy (1/3 the curative dose of praziquantel plus 1/3 the curative dose of oxamniquine) was compared with the effect of each drug alone, in reduced or full dose. Comparison with infected untreated controls was also made.

Pharmacological effects of althesin and its steroidal components on the cardiovascular system.

Althesin and its two steroidal components elicited, despite a deficit vasopressor effect by their solvent vehicle Cremophor El, a well-marked hypotensive activity appearing abruptly after i.v. injection in chloralosed cats.