Publications by authors named "N E Tomita"

Objectives: To compare thoracolumbar fascia (TLF) shear strain between individuals with and without nonspecific low back pain (NSLBP), investigate its correlation with symptoms, and assess a standardized massage technique's impact on TLF shear strain.

Methods: Participants were prospectively enrolled between February 2021 and June 2022. Pre- and post-intervention TLF ultrasound and pain/disability questionnaires were conducted.

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Grading activity of inflammatory bowel disease (IBD) using standardized histopathological scoring systems remains challenging due to limited availability of pathologists with IBD expertise and inter-observer variability. In this study, a deep learning model was developed to classify activity grades in hematoxylin and eosin-stained whole slide images (WSIs) from patients with IBD, offering a robust approach for general pathologists. This study utilized 2,077 WSIs from 636 patients who visited Dartmouth-Hitchcock Medical Center in 2018 and 2019, scanned at 40× magnification (0.

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Although lenalidomide is an essential treatment for multiple myeloma (MM), skin rashes are a common adverse event. This retrospective study aimed to examine the association between skin rash development during lenalidomide treatment and the prognosis of relapsed/refractory MM. All patients who received lenalidomide at 10 hospitals between July 2009 and December 2015 were included in the study.

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  • The study aimed to identify dosimetric factors that predict the risk of brain necrosis (BN) in patients undergoing fractionated stereotactic radiotherapy (SRT) for brain metastases.
  • Researchers used multivariate logistic models to analyze data from patients who received various SRT doses, calculating the volume of normal brain exposed to specific biological doses (VxxEQD2).
  • Results indicated that larger volumes of the brain receiving higher doses (V55EQD2 and V60EQD2) were associated with increased chances of developing symptomatic BN, emphasizing the need for careful planning to minimize exposure.
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  • A study explored the effectiveness of the oral human papillomavirus (HPV) vaccine IGMKK16E7 in treating cervical intraepithelial neoplasia, showing promising results where some patients experienced a complete histological response.
  • Researchers analyzed cervix-exfoliated cell samples from 42 patients to identify biomarkers that could predict the success of the vaccine, focusing on various gene expressions related to immune response.
  • The key finding was that lower levels of the biomarker CD86 correlated with a higher likelihood of achieving a complete response to the vaccine, with CD86-low patients demonstrating a significantly increased response rate compared to those with higher CD86 levels.
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