Publications by authors named "N E Sy"
Dopaminergic and anti-estrogenic responses in juvenile steelhead (Oncorhynchus mykiss) exposed to bifenthrin.
Comp Biochem Physiol C Toxicol Pharmacol
November 2024
Article Synopsis
- * Juvenile steelhead exposed to low concentrations of bifenthrin exhibited increased dopamine levels in their brains, alongside decreased expression of key genes linked to dopamine and estrogen signaling.
- * The study suggests that bifenthrin may disrupt dopaminergic pathways and endocrine functions in juvenile steelhead, underscoring the necessity of understanding how pesticides affect different species and life stages to improve risk assessments.
Background: Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. Pathogen genomic surveillance could be invaluable for monitoring current and emerging parasite drug resistance.
Methods: Data from two decades (2000-2020) of continuous molecular surveillance of P.
Article Synopsis
- Genetic surveillance of Plasmodium falciparum can help National Malaria Control Programmes estimate parasite transmission using metrics like multi-strain infections and infection complexity, despite uncertainties about their ability to directly predict clinical incidence.
- In a study involving 3,147 clinical infections across Senegal from 2012-2020, researchers used genetic analysis to correlate genetic metrics with malaria incidence at different clinic sites.
- Results indicated that genetic metrics reliably predicted incidence when transmission was high (over 10 cases per 1,000 annually), but showed reversed correlations at lower transmission levels, suggesting a limit to the use of genetics in estimating incidence during low transmission periods.
The worldwide decline in malaria incidence is revealing the extensive burden of non-malarial febrile illness (NMFI), which remains poorly understood and difficult to diagnose. To characterize NMFI in Senegal, we collected venous blood and clinical metadata in a cross-sectional study of febrile patients and healthy controls in a low malaria burden area. Using 16S and untargeted sequencing, we detected viral, bacterial, or eukaryotic pathogens in 23% (38/163) of NMFI cases.
View Article and Find Full Text PDFMany contaminants of emerging concern (CECs) have reactive functional groups and may readily undergo biotransformations, such as methylation and demethylation. These transformations have been reported to occur during human metabolism and wastewater treatment, leading to the propagation of CECs. When treated wastewater and biosolids are used in agriculture, CECs and their transformation products (TPs) are introduced into soil-plant systems.
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