[Changes of human immunophenotype during adaptation to environmental factors, in different forms of pathology and their specific treatment].

The aim of the study was to elucidate mechanisms underlying variations of human immune phenotype in the course of adaptation to environmental factors, development of different forms of pathology and their specific treatment from dynamics of expression of surface CD-molecules in lymphocyte plasmolemma and immunoglobulin A, M, G levels in blood plasma. 253 assumingly healthy volunteers residing in the Moscow Megapolis exhibited a tendency toward enhanced lymphocyte apoptosis and reduced efficiency of their co-stimulation and cooperative interaction. Pathologies of different etiology were associated with the imbalance of specific and non-specific reactions of immune and biological control.

[A panel of monoclonal antibodies against human lymphocyte antigens].

Monoclonal antibodies (McAb) LT1, LT2, LT4, LT6, LT7, LT8, LB21 and LDR to surface antigens of human lymphocytes have been obtained. Basing on the data concerning the distribution of McAb reactivity with cells from different organs and tissues, and with tumour cell lines, on experiments on the mutual blockage and comodulation of antigens, on two-colour immunofluorescence and determination of the molecular weight of the detected antigens a conclusion is made that the McAb obtained react with CD5, CD2, CD4, CD6, CD7, CD8, CD21 and HLA-DR antigens, respectively. McAb LT1 and Leu1, as well as LT2 and Leu5b in pairs blocked each other completely.