Patient positioning in static beams for boron neutron capture therapy of malignant glioma.

Purpose: To develop a procedure for the optimum patient positioning and immobilization during boron neutron capture therapy (BNCT) of glioblastoma multiforme (GBM) at the Brookhaven medical research reactor (BMRR).

Methods: A replica of the treatment room in the BMRR was constructed to simulate patient position. A unique feature is a transparent opening in wall to simulate the location of the beam port and to provide a beam-eye view of the head.

Boron neutron capture therapy for glioblastoma multiforme: interim results from the phase I/II dose-escalation studies.

OBJECTIVE: The primary objective of these Phase I/II dose-escalation studies is to evaluate the safety of boronophenylalanine (BPA)-fructose-mediated boron neutron capture therapy (BNCT) for patients with glioblastoma multiforme (GBM). A secondary purpose is to assess the palliation of GBM by BNCT, if possible. METHODS: Thirty-eight patients with GBM have been treated.