Publications by authors named "N E Morton"
Article Synopsis
- This review highlights the difficulty of pinpointing causal genetic variants in quantitative trait loci (QTLs) linked to complex traits and diseases, even as the number of loci identified increases.
- The authors suggest combining bioinformatics and multiomics analyses to improve the identification of candidate gene variants, making the process more efficient.
- A case study on the Pla2g4e gene shows that using multiomic data alongside regulatory elements can help narrow down the search for causative variants, ultimately aiding faster genetic research, functional validation, and therapeutic advancements.
Article Synopsis
- Systemic excess of glucocorticoids, such as in Cushing's syndrome, leads to various metabolic issues, influenced by the enzyme 11β-HSD1.
- A study on mice revealed that high doses of corticosterone increased metabolic rates and carbohydrate use, especially in female wild type (WT) mice, but also caused fat accumulation.
- Notably, 11β-HSD1 knockout mice were protected from these metabolic changes, highlighting its role in the effects of glucocorticoid excess and hyperphagia.
The ESPA Pain Management Ladder Initiative is a clinical practice advisory based upon expert consensus supported by the current literature to help ensure a basic standard of perioperative pain management for all children. In 2018 the perioperative pain management of six common pediatric surgical procedures was summarised. The current Pain Management Ladder recommendations focus on five more complex pediatric surgical procedures and suggest basic, intermediate, and advanced pain management methods.
View Article and Find Full Text PDFHydrogen sulfide (H2S) played a pivotal role in the early evolution of life on Earth before the predominance of atmospheric oxygen. The legacy of a persistent role for H2S in life's processes recently emerged through its discovery in modern biochemistry as an endogenous cellular signalling modulator involved in numerous biological processes. One major mechanism through which H2S signals is protein cysteine persulfidation, an oxidative post-translational modification.
View Article and Find Full Text PDFEnhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency of the oxygen-sensor HIF-prolyl hydroxylase (PHD2) gene overcomes BAT dormancy at thermoneutrality.
View Article and Find Full Text PDF