CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety.

CDK4/6 inhibitors have revolutionized treatment of hormone receptor positive (HR+), HER2 non-amplified (HER2-) breast cancer. Yet, all "dual" CDK4/6 inhibitors show common dose-limiting hematologic toxicities, foremost neutropenia. This poses challenges to provide these agents at concentrations necessary to extinguish cell cycling in tumors.

A deep insight into the sialome of the house fly, Musca domestica, infected with the salivary gland hypertrophy virus (MdSGHV).

The house fly, Musca domestica, serves as a mechanical vector for numerous pathogens, posing a significant risk to human and animal health. More than two decades ago, the Musca domestica salivary gland hypertrophy virus (MdSGHV) was discovered, infecting both males and females flies and disrupting mating and the reproductive process. While MdSGHV can infect various tissues, its primary replication site is the house fly salivary gland.

Alkane Monooxygenase (FtAlkB) Is an Alkyl Fluoride Dehalogenase.

Purified alkane monooxygenase (AlkB) from (FtAlkB) catalyzes the defluorination of 1-fluorooctane, producing octanal, which is partially reduced under the reaction conditions to generate 1-octanol. This reaction occurs preferentially at the monofluorinated methyl group, with only a minor amount of oxidation at the nonfluorinated end of the molecule. The dehalogenation chemistry is specific to 1-fluorooctane, as neither 1-chlorooctane or 1-bromooctane are dehalogenated to an appreciable extent.

Psychedelics: Safety and Efficacy.

Psychedelic research has experienced a renaissance in recent years, with many researchers exploring the possible therapeutic effects of these drugs. Medical institutions, universities, pharmaceutical companies, and governmental institutions alike have been showing an increase in support of this research, as shown through the recent establishment of various psychedelic research facilities across the United States. However, the safety and efficacy of psychedelic usage are not the focus of the existing research.