Publications by authors named "N E Maximova"
Alternating hemiplegia of childhood (AHC) is a rare neurological disorder that usually manifests before 18 months of age and is characterized by recurrent, alternating episodes of hemiparesis with variable frequency and can last from a few minutes to several days. We present a case of AHC in a little girl carrying a sporadic mutation in the ATP1A3 gene (p.Glu815Lys) refractory to flunarizine and non-compliant to topiramate due to adverse effects treated with oral compound of adenosine-5'-triphosphate (ATP) capsules.
View Article and Find Full Text PDFIntroduction: High-dose methotrexate (MTX) is used to treat pediatric acute lymphoblastic leukemia (ALL). The drug has a low therapeutic index and a highly interindividual variability in systemic exposure. These characteristics necessitate dose adjustments and therapeutic drug monitoring protocols, while population pharmacokinetic (POP/PK) models may enable more precise drug dosing.
View Article and Find Full Text PDFArticle Synopsis
- Pediatric patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) face risks related to their nutritional status, specifically body mass index (BMI), which affects transplantation success.
- A study analyzed BMI data from patients treated between 2003 and 2023 and found that underweight patients had significantly lower survival rates and higher complications compared to those with normal or higher BMI.
- The research emphasizes the need for regular nutritional assessment before and after transplant to improve outcomes, suggesting that BMI should be closely monitored to manage risks effectively.
This report describes a pediatric case of isolated agranulocytosis occurring months after hematopoietic stem cell transplantation (HSCT). Secondary cytopenia, or secondary transplant failure, affects 10%-25% of HSCT recipients, with potential triggers including viral infection, graft-versus-host disease (GVHD), sepsis, and certain medications. Viral reactivation was ruled out based on negative PCR results, while GVHD and sepsis were ruled out based on the patient's clinical presentation.
View Article and Find Full Text PDFBackground: Central line-associated bloodstream infections (CLABSIs) are critical infectious complications among pediatric hematology-oncology patients, and the management of central venous catheters (CVCs) by healthcare personnel can significantly influence the incidence of these infections. This study evaluates the impact of nurse-led changes in CVC management on the incidence of CLABSIs.
Methods: This single-center, retrospective observational study was conducted at an urban, tertiary referral, and academic center serving pediatric patients.