[Evaluating efficiency of combined vaccination against influenza and pneumococcal infection in workers of "Gazprom transgaz Yekaterinburg" company].

Influenza-like diseases are among the causes of disability. Risk of these diseases is increased with other occupational hazards. The study covered efficiency of combined vaccination against influenza (annually, over 2 years, with inactivated split-vaccine Vaxigrip) and pneumococcal infection (single, with 23-valent pneumococcal polysaccharide vaccine Pneumo 23) in 318 workers of Neviansk branch of "Gazprom transgaz Yekaterinburg" company.

[Simultaneous quantification of soluble fibrin and D-dimer in blood plasma for the assessment of the threat of thrombosis].

Soluble fibrin and D-dimer are the most specific markers of blood coagulation cascade and the threat of thrombosis. Two immunoassay test systems were designed using the fibrin-specific and D-dimer-specific monoclonal antibodies. The clinical trials of the test systems were carried out in Ukraine.

Foot and mouth disease virus polyepitope protein produced in bacteria and plants induces protective immunity in guinea pigs.

The goal of this project was to develop an alternative foot and mouth disease (FMD) vaccine candidate based on a recombinant protein consisting of efficient viral epitopes. A recombinant gene was designed that encodes B-cell epitopes of proteins VP1 and VP4 and T-cell epitopes of proteins 2C and 3D. The polyepitope protein (H-PE) was produced in E.

[Development of an indirect ELISA for the detection of antibodies to swine vesicular disease virus during monitoring studies].

An indirect ELISA (I-ELISA) has been developed for swine vesicular disease virus-specific antibody detection. The analytic sensitivity of I-ELISA testing of serum samples from experimentally infected pigs with the known VN titer was 2 log2. Its diagnostic specificity was demonstrated as 100% in 4485 swine serum samples from different regions of the Russian Federation.

[Comparison of different ELISAs for detection of antibodies to swine vesicular disease virus in sera from experimentally infected animals].

The study has shown the efficiency of a competitive ELISA (C-ELISA) variant or an indirect ELISA (I-ELUSA) in the detection of antibodies to swine vesicular disease virus (SVDV) versus traditional assays, such as a microneutralization test, a blocking ELIDA test, and a the reference test Ceditest SVDV (Cedi-Diagnostics B.V., Netherlands).