Publications by authors named "N E Judge"
Article Synopsis
- Poly(ε-caprolactone) (PCL) is commonly used in the biomedical field, but it has a long degradation time, which limits its applications.
- Researchers developed a semiaromatic polyester-ether (SAEE) PCL copolymer using a salicylic acid monomer that alters PCL's structural properties, resulting in a decrease in melting and crystallization temperatures with increased SAEE content.
- The study found that by adjusting the SAEE percentage, they could significantly enhance the thermal, mechanical, and degradation characteristics of the PCL copolymers, achieving total mass loss in a shorter timeframe while preserving beneficial biological properties.
The first report of star poly(L-proline) crosslinkers is disclosed for digital light processing 3D printing of thermoresponsive hydrogels. Through chain end functionalization of star poly(L-proline)s with methacryloyl groups, access to high-resolution defined 3D hydrogel structures via digital light processing is achieved through photoinitiated free radical polymerization. Changing the poly(L-proline) molecular weight has a direct influence on both thermoresponsiveness and printability, while shape-morphing behavior can be induced thermally.
View Article and Find Full Text PDFDigital light processing (DLP) printing forms solid constructs from fluidic resins by photochemically crosslinking polymeric resins with reactive functional groups. DLP is used widely due to its efficient, high-resolution printing, but its use and translational potential has been limited in some applications as state-of-the-art resins experience unpredictable and anisotropic part shrinkage due to the use of solvent needed to reduce resin viscosity and layer dependent crosslinking. Herein, poly(allyl glycidyl ether succinate) (PAGES), a low viscosity, degradable polyester, was synthesized by ring opening copolymerization and used in combination with degradable thiol crosslinkers to afford a solvent free resin that can be utilized in DLP printing.
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- Scientists found that two weak bases, Zn(TMP) and KOBu, work together to create a strong base. This can help them add zinc to certain organic compounds (like naphthalene and caffeine) under easy conditions.
- The process lets them make specific products, like iodo-(hetero)arenes, and they can control exactly where the zinc attaches on these compounds.
- They also discovered that the zinc compounds can change based on the solvent used, and that over time, the materials can react with the solvent to create a different product. This shows there's a lot going on when these chemicals interact!
Macrophage metabolic plasticity is central to inflammatory programming, yet mechanisms of coordinating metabolic and inflammatory programs during infection are poorly defined. Here, we show that type I interferon (IFN) temporally guides metabolic control of inflammation during methicillin-resistant Staphylococcus aureus (MRSA) infection. We find that staggered Toll-like receptor and type I IFN signaling in macrophages permit a transient energetic state of combined oxidative phosphorylation (OXPHOS) and aerobic glycolysis followed by inducible nitric oxide synthase (iNOS)-mediated OXPHOS disruption.
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