Publications by authors named "N E Jorge"
Many publicly available databases provide disease related data, that makes it possible to link genomic data to medical and meta-data. The cancer genome atlas (TCGA), for example, compiles tens of thousand of datasets covering a wide array of cancer types. Here we introduce an interactive and highly automatized TCGA-based workflow that links and analyses epigenomic and transcriptomic data with treatment and survival data in order to identify possible biomarkers that indicate treatment success.
View Article and Find Full Text PDFTetroxane derivatives are interesting drugs for antileishmaniasis and antimalaric treatments. The gas-phase thermal decomposition of 3,6,-dimethyl-1,2,4,5-tetroxane (DMT) and 3,3,6,6,-tetramethyl-1,2,4,5-tetroxane (acetone diperoxide (ACDP)) was studied at 493-543 K by direct gas chromatography by means of a flow reactor. The reaction is produced in the injector chamber at different temperatures.
View Article and Find Full Text PDFArticle Synopsis
- The use of antibiotics in agriculture has significantly increased, leading to rising levels of these substances in soil, particularly from intensive farming and human consumption.
- This study examines how ciprofloxacin, an antibiotic, interacts with clay minerals in soils from Santa Rosa, Argentina, using both experimental methods and atomistic modeling.
- Findings reveal two types of ciprofloxacin adsorption on clay minerals: a weakly bound form that gets released during desorption and a strongly bound form that persists in the soil.
Invasive pneumococcal disease is a serious infection with an elevated case-fatality rate that can be even higher among patients with asplenia. Its impact has been blunted by the widespread use of vaccines; even recently, in 2021, two new pneumococcal conjugate vaccines emerged. The authors present a case of a 58-year-old male, splenectomised with the immunisation schedule complete, who died of invasive pneumococcal disease with a fulminant course.
View Article and Find Full Text PDFCritically ill patients with high predicted mortality: Incidence and outcome.
Med Intensiva (Engl Ed)
February 2024
Article Synopsis
- A significant portion of ICU patients (12.2%) have a high predicted mortality rate (over 80%) upon admission, highlighting a vulnerable population that lacks adequate clinical study.
- Despite a high Simplified Acute Physiology Score II (SAPS II) indicating an average predicted mortality of 89%, actual observed mortality was significantly lower at 61%.
- By one year post-ICU admission, about 30% of this high-risk group remained alive, indicating better-than-expected survival rates compared to initial predictions.