[The bone regeneration process under chymotrypsin exposure (an experimental study)].

Disturbance of femur diaphysis compact substance was induced experimentally in rabbits. In the course of the operation single administration of crystalline chimotripsin into the wound was performed and its influence on bony structures regeneration was studied. Methods of light and scanning electron microscopy revealed that reparative processes started earlier and were more active than that in control.

[Embryonal morphogenesis of the intraorgan circulatory bed, lymphatic outflow pathways and innervation structures].

Development of the circulation bed in human embryogenesis is brought about by a loop-like growth of vessels manifesting in proliferation, integration and morphofunctional transformation of the vascular loops. Proliferation of the loops ensures the blood inflow and reflux at all levels while their integration is followed by formation of hemocirculation system with appearance of the connective and major capillaries which serve the basis for development of true capillaries and capillary network in which precapillary arterioles and postcapillary venules can be distinguished. Hemocirculation system is completed by formation of the arteriolar and venular collaterals and arteriolo-venular anastomoses.

[The loop-like growth of the vessels and the embryonic morphogenesis of the human intraorganic circulatory system].

Development of the vascular bed during embryogenesis in man occurs through loop-like growth of vessels appearing as multiplication, integration, and morphofunctional transformation of vessel loops. Growth of loops provides for the establishment of transport vessels in organs and tissues, and loop integration leads to the establishment of microcirculation with the appearance of connecting and major capillaries, from which true capillaries and capillary networks are formed. Precapillary arterioles and postcapillary venules can be identified topographically in the capillary networks.

[Morphologic manifestations of microcirculatory system pathology in premature infants].

Immaturity of the interchangeable part of the microhemocirculatory bed manifested in premature neonates by true capillary insufficiency and capillary trophic failure of the microhemocirculation system. Primary functional heart failure results in hypovolemia of the greater circulation followed in early postnatal period by slow formation of new microvessels, on the one hand, and by collapse and reduction of vascular terminals, on the other. These alterations enhance the existing tissue trophic deficiency of the microcirculatory bed and decrease functional capacities of the cardiovascular system.

[Importance of programmed endothelial death in the formation of intraorgan vascular bed in human embryogenesis].

The development of the intraorgan vascular bed is brought about by means of a loop-like vascular growth which forms not only arteries and veins of all levels but that of microcirculation system as well. Embryonal angiogenesis is followed by a programmed death of the endothelium of all autochtone structures and some functioning microvessels of a closed circulation. This process is of importance in remodelling of vascular bed and formation of collateral circulation and anastomoses.