Larval stress affects adult Drosophila behavior and metabolism.

In this study, we raised the following question: "Does metamorphosis, being a "reboot" of all systems of the organism, erase the changes that occurred at earlier stages of insect development?" To answer this question, we investigated several behavioral, metabolic and neuroendocrine parameters in Drosophila melanogaster imago that had undergone heat stress at the 3rd larval instar (32 °C, 48 h). We discovered that larval stress negatively affected feeding and locomotor behavior, as well as total lipid content in adult flies. At the same time, these flies demonstrated a considerable increase in carbohydrate content and expression level of insulin/insulin-like growth factor signaling (IIS) pathway genes, dfoxo, dilp6 and dInR.

Two Old Wild-Type Strains of Can Serve as an Animal Model of Faster and Slower Aging Processes.

Background: provides a powerful platform to study the physiology and genetics of aging, i.e., the mechanisms underpinnings healthy aging, age-associated disorders, and acceleration of the aging process under adverse environmental conditions.

Fertility differences between two wild-type Drosophila melanogaster lines correlate with differences in the expression of the Jheh1 gene, which codes for an enzyme degrading juvenile hormone.

Juvenile hormone plays a "status quo" role in Drosophila melanogaster larvae, preventing the untimely metamorphosis, and performs a gonadotropic function in imagoes, ensuring the ovaries' preparedness for vitellogenesis. The decreased level of juvenile hormone results in reproductive disorders in D. melanogaster females including a delay in the oviposition onset and a fertility decrease.

The Effect of Genotype Combinations of and Its Host on Fertility, Developmental Rate and Heat Stress Resistance of Flies.

The best-known effect of the intracellular bacterium is its mostly negative influence on the reproduction of the host. However, there is evidence of a positive influence of on the host's resistance to stress, pathogens, and viruses. Here, we analyzed the effects of two strains belonging to wMel and wMelCS genotypes on traits, such as fertility, survival under acute heat stress, and developmental rate.