[Surgical correction of urogenital sinus in girls].

Aim: To analyze the diagnostics results and surgical outcomes in girls with congenital urogenital sinus.

Materials And Methods: A total of 9 girls with urogenital sinus were evaluated and treated in the clinical base of the Department of Hospital Pediatric Surgery with a course of oncology at TashPMI during the period from 2009 to 2019.

Results: The results of diagnostics and treatment of 9 patients with various forms of urogenital sinus are presented.

[Features of clinical picture and diagnostic aspects of intestional rotation and fixation disorders in children].

Clinical manifestations and diagnostic methods of particular anatomical variants of intestinal rotation and fixation disorders were discussed by the authors in 208 children of different age groups. There was revealed the tendency to reduce rotation abnormalities diversity with the increase of age group. At the same time the frequency of occurrence of the colon fixation anomalies characterized by chronic recurrent process and progressing colostasis was enlarged.

[Indications and results of colostomy for anorectal malformations in girls].

On the basis of an analysis of 122 cases the authors present options on the strategy and methods of operations depending on the anatomical patterns, the degree of anorectal malformations and the type of coexisting pathology, the technique of placing unnatural anus. Preference is given to a one-stage surgical method, the indications to the graded treatment with the formation of colostomy are described in detail.

[Sexual specificity of change of pancreatic alpha-amylase activity in rats in cadmium intoxication].

It was shown that the activity of alpha-amylase in the pancreas tissue, intestine content and blood, as well as kinetic characteristics in different substratum concentration changed in males and females after unitary oral administration of chloride cadmium in the dose 5 mg/kg. It was revealed that, after a single administration of chloride cadmium, growth of the pancreas weight, contents of protein and activity of alpha-amylase in the pancreatic tissue increased with parallel reduction of activity of enzyme in the small intestine. In acute cadmium intoxication, functional reorganizations in the pancreas are identical to initial stages of carcinogenic shifts.

[Activity of digestive enzymes in offspring of rats fed a ration contaminated by heavy metals during lactation].

Is was shown the consumption of heavy metal's salts with food by lactating rats, essential influences on formation of mechanisms of cavity and membrane digestive in offspring. This influence is shown in repression of activity of pancreatic alpha-amylase and enteral saccrase, maltase as well as in induction of lactase activity in growing rats.