Publications by authors named "N E Cunningham"
Background/objectives: Host cell protein (HCP) content is a major attribute for biological and vaccine products that must be extensively characterized prior to product licensure. Enzyme Linked Immunosorbent Assay (ELISA) and Mass Spectrometry (MS) are conventional methods for quantitative host cell protein analysis in biologic and vaccine products. Both techniques are usually very tedious, labor-intensive, and challenging to transfer to other laboratories.
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- * Thirty-three studies involving 2,676 participants showed that psychological interventions significantly reduced anxiety levels, but they did not notably improve functional impairment or HRQOL; the studies generally had some risk of bias.
- * The findings suggest that psychological interventions, especially those involving live therapists, can help lower anxiety in youth with CMCs, but more high-quality research is necessary to identify which therapy components work best.
Background/objectives: This paper details the development of the Helping Educators Learn Pediatric Pain Assessment and Intervention Needs (HELP PAIN) program.
Methods: HELP PAIN is an 8 h live training program for school providers (e.g.
Sedimentation velocity, using an analytical ultracentrifuge equipped with fluorescence detection, and electrophoresis methods are used to study aggregation of proteins in transgenic animal model systems. Our previous work validated the power of this approach in an analysis of mutant huntingtin aggregation. We demonstrate that this method can be applied to another neurodegenerative disease studying the aggregation of three dipeptide repeats (DPRs) produced by aberrant translation of mutant c9orf72 containing large GC hexanucleotide repeats.
View Article and Find Full Text PDFObjectives: Pediatric chronic pain is common and can be detrimental to children's social, emotional, and school functioning. Nonpharmacological approaches to chronic pain, like cognitive- behavioral therapy (CBT), can be effective. Schools could provide children with chronic pain access to these interventions.
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