Publications by authors named "N E Binder"
Purpose: Our aim is to evaluate the sensitivity and specificity of Acuity 360 telemedicine system, as compared to in-person clinic examination, in identifying clinically significant eye disease. Acuity 360 is a combination of commercially available ocular imaging devices used together to provide a comprehensive evaluation of the structures and diseases of the eye.
Methods: Observational cross-sectional study of consecutively examined patients where 19 remote examiners analyzed 80 patients using Acuity 360 images.
The identification of similar patient pathways is a crucial task in healthcare analytics. A flexible tool to address this issue are parametric competing risks models, where transition intensities may be specified by a variety of parametric distributions, thus in particular being possibly time-dependent. We assess the similarity between two such models by examining the transitions between different health states.
View Article and Find Full Text PDFObjectives: Potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs) are common in multimorbid patients. This study aims to describe PIMs and PPOs in an open-access outpatient setting and to investigate any association between continuity of care (CoC) and PIMs and PPOs in multimorbid older patients.
Design: Cross-sectional study using patient-confirmed outpatient medication plans to describe PIMs and PPOs using the 'Screening Tool of Older Person's Prescription/Screening Tool to Alert to Right Treatment' version 2.
Article Synopsis
- Preeclampsia is a pregnancy condition linked to abnormal maternal blood vessel function, and C-type natriuretic peptide (CNP) is being studied for its ability to improve vascular health during this condition.
- The study involved analyzing human arteries from women with preeclampsia and healthy pregnancies to see how CNP affects artery dilation in a preeclampsia model using various constricting agents.
- Results showed that while CNP effectively relaxed arteries from the preeclampsia model, it primarily worked through the NPR-B receptor, indicating that enhancing CNP signaling could be a potential treatment strategy for preeclampsia-related vascular issues.
Article Synopsis
- Factor VIII inhibitors are traditionally measured using cumbersome Nijmegen or Bethesda assays, which are time-consuming and inconsistent in quality due to manual labor.
- This study introduces a new fully automated assay for measuring FVIII inhibitors using recombinant FVIII, significantly reducing incubation time and improving efficiency with advanced equipment.
- The new method demonstrated high sensitivity and consistency, with strong correlation to existing assays, making it a promising alternative for clinical use.