Publications by authors named "N E Bergeron"
Despite advancements in treatment, approximately 25% of patients with breast cancer experience long-term skeletal muscle wasting (SMW), which limits mobility, reduces drug tolerance and adversely impacts survival. By understanding the underlying molecular mechanisms of SMW, we may be able to develop new strategies to alleviate this condition and improve the lives of patients with breast cancer. Chemokines are small soluble factors that regulate homing of immune cells to tissues during inflammation.
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- Alport syndrome is linked to three genes (COL4A3, COL4A4, COL4A5) and is marked by kidney issues like glomerulosclerosis and changes in the glomerular basement membrane.
- A study reported a mother and son with COL4A5-related Alport syndrome, sharing unusual kidney biopsy results and a specific genetic variant (p.Gly1170Ser).
- Findings indicate that changes in collagen expression in Bowman's capsule might be more affected by mutations in COL4A5, suggesting that certain genetic variants can play a significant role in how the disease presents.