Publications by authors named "N E Alexis"
Cough Variant Asthma: The Asthma Phenotype No One Coughs About.
Am J Respir Cell Mol Biol
November 2024
Background: Inhalation of biomass smoke is associated with adverse respiratory effects in those with chronic pulmonary conditions. There are few published data regarding the effects of anti-inflammatory interventions on these outcomes.
Objective: Our aim was to assess the effects of postexposure prednisone on woodsmoke (WS)-induced sputum neutrophilia.
Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study.
Chronic Obstr Pulm Dis
September 2024
Article Synopsis
- The SPIROMICS Study of Early COPD Progression (SOURCE) aims to investigate the biological reasons behind early-stage COPD in younger individuals who smoke, addressing a gap in current medical knowledge that hinders treatment development.
- The study plans to enroll 649 participants aged 30-55 with a history of smoking, alongside 40 never-smoker controls, to collect comprehensive health data and analyze potential mechanisms of disease progression.
- SOURCE seeks to use advanced imaging and biospecimen collection methods over three years to enhance understanding of COPD and contribute to better prevention and treatment strategies.
The airway microbiome has the potential to shape chronic obstructive pulmonary disease (COPD) pathogenesis, but its relationship to outcomes in milder disease is unestablished. To identify sputum microbiome characteristics associated with markers of COPD in participants of the Subpopulations and Intermediate Outcome Measures of COPD Study (SPIROMICS). Sputum DNA from 877 participants was analyzed using 16S ribosomal RNA gene sequencing.
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