Effect of alpha-methyldopa on cardiac output in hypertension.

Hemodynamic and blood volume changes, systolic time intervals, and baroreflex mechanisms were studied in 20 patients with hypertension after methyldopa (12 +/- 0.9 mg/kg/day). The drug was administered orally during 7 days' hospitalization on a normal sodium diet (110 mEq/day).

[Electrocardiographic evolution of severe medically treated hypertension].

Electrocardiographic finding were studied in 34 severe hypertensions submitted to antihypertensive therapy. The duration of the survey was between 2 and 6 years. No significant correlation was observed between the changes in pressure and the changes in electrocardiogramm: normalisation of blood pressure could be associated with abnormalities in the electrocardiogramm, concerning especially ST segments and T waves.

Extracellular fluid volume and renal indices in essential hypertension.

Extracellular fluid volume (EFV), total blood volume (TBV), and renal indices were determined in 53 permanent essential hypertensive patients with normal renal function and balanced sodium intake and urinary output. In comparison with normal subjects, hypertensives had normal EFV values while TBV and the TBV/EFV ratio were significantly reduced (p less than 0.001).

[Essential hypertension: long term haemodynamic effects of a diuretic combination (cyclothiazide-triamterene) (author's transl)].

The long terme hemodynamic effect of cyclothiazide 3 mg-triamterene 150 mg was studied in 10 patients with permanent essential hypertension. Diuretic therapy induced a significant fall in blood pressure (p less than 0.001) and total peripheral resistance (p less than 0.