Publications by authors named "N Duzgun"
Behçet's disease is a complex inflammatory vasculitis with a broad spectrum of clinical manifestations. The purpose of this study was to investigate the genetics underlying specific clinical features of Behçet's disease. A total of 436 patients with Behçet's disease from Turkey were studied.
View Article and Find Full Text PDFObjectives: Behçet's disease tends to be more severe in men than women. This study was undertaken to investigate sex-specific genetic effects in Behçet's disease.
Methods: A total of 1762 male and 1216 female patients with Behçet's disease from six diverse populations were studied, with the majority of patients of Turkish origin.
Article Synopsis
- Behçet's disease is a complex inflammatory condition with unclear causes, and this study aimed to explore its genetic connections within a diverse population.* -
- The study included 9,444 participants from 7 backgrounds and found 2 new genetic risk markers associated with the disease, along with confirming 6 previously known ones.* -
- These results suggest significant genetic influences across different ethnicities and open avenues for further research into the underlying mechanisms of Behçet's disease.*
Article Synopsis
- Takayasu arteritis is a rare inflammatory disease affecting large arteries and was studied in a large genetic analysis of over 6,600 individuals, revealing significant genetic factors involved.
- Researchers identified specific HLA risk factors and several non-HLA susceptibility genes, including VPS8 and CFL2, that contribute to the disease, with ETS2 highlighted as a potential key gene.
- The study found strong genetic links between Takayasu arteritis and inflammatory bowel disease, suggesting potential therapeutic targets and enhancing understanding of the disease's genetic underpinnings.