Prevalence of high-grade cervical intraepithelial neoplasia in women with persistent high-risk HPV genotypes and negative cytology.

Introduction: Primary HPV screening will be implemented into the English Cervical Screening Programme by 2019. Its impact upon women referred to colposcopy, with negative cytology but persistently positive high-risk HPV (hrHPV), remains unreported from UK Sentinel sites. HPV primary screening was introduced in Sheffield, UK in April 2013; this paper reports its impact on the service.

Cytology in the diagnosis of cervical cancer in symptomatic young women: a retrospective review.

Background: Cervical cancer in young women presents a diagnostic challenge because gynaecological symptoms are common but underlying disease is rare.

Aim: To explore the potential for using cytology as a diagnostic aid for cervical cancer in young women.

Design And Setting: Retrospective review of primary care records and cytology data from the national cervical screening database and national audit of cervical cancers.

Cytology training in the UK: a training centre prospective.

Training in both cervical and non-gynaecological cytology in the UK has never faced a more challenging environment. A national reconfiguration of cervical cytology services has focussed resources on large centres and damaged the traditional links and overlapping roles within non-gynaecological cytology. The UK is now at significant risk of falling behind most European countries in the use of non-gynaecological cytology.

Endometrial Adenocarcinoma in SurePath™ Cervical Samples: Cytological Features Revisited.

Objective: The cytomorphological criteria of malignant endometrial lesions in cervical samples are less well described than those of cervical lesions. We wished to investigate if there were features in SurePath™ liquid-based cytology samples that would facilitate more accurate differentiation between benign and malignant endometrial cells.

Study Design: This was a two-phase study, with a review of all SurePath™ samples reported as endometrial adenocarcinoma (n = 42) evaluating 12 cytological features in the first phase.