Publications by authors named "N Dubois"
Unlabelled: Industrial activities of a silk dyeing factory in Thalwil, on the shore of Lake Zurich, Switzerland, caused extreme Sn contamination of lake sediments. In this study, we determine the contamination source, spread, and age using a multiproxy approach. We used X-ray fluorescence spectroscopy (XRF) core scanning and further geochemical analyses to assess the contamination spreading and thickness in the sedimentary column.
View Article and Find Full Text PDFFaculty development in medical simulation is a growing need, given the increased use of simulation-based learning in healthcare. Training of trainers is demanding and resource-consuming; therefore, there is a need for accessible, practical, and resource-saving solutions enabling efficient faculty development. For that purpose, we investigated whether a massive open online course (MOOC) could meet these challenges.
View Article and Find Full Text PDFRemote Oceania was among the last places settled by humans. However, the timing of initial human settlements and the early introduction of horticulture remain debated. We retrieved a sediment core close to Teouma, the oldest cemetery in Remote Oceania that reveals evidence of initial settlement, horticulture practice, and concurrent climatic conditions on the island of Efate, Vanuatu.
View Article and Find Full Text PDFArticle Synopsis
- Cardiac Purkinje fibers are crucial for coordinating heart contractions and understanding their biology is limited due to challenges in creating these cells from human stem cells.
- Researchers analyzed single-cell data from mouse hearts to identify key signaling pathways, such as Notch signaling, that are involved in the formation of Purkinje fiber cells.
- Activating Notch signaling in human embryonic stem cell-derived cardiomyocytes not only transformed their shape and electrical properties to resemble Purkinje fibers but also altered their gene expression, resulting in lower contractile force and differing responses to anti-arrhythmogenic drugs.
Article Synopsis
- A study investigates how drug-induced gene expression profiles can reveal mechanisms of cardiotoxicity in FDA-approved tyrosine kinase inhibitors (TKIs) using human stem cell-derived heart cells.
- The research employs singular value decomposition to detect drug-specific patterns in cells from various healthy individuals, highlighting affected cellular pathways like energy metabolism and contractile functions.
- The findings suggest that integrating mRNA expression data with genomic and pathway information can create comprehensive signatures for cardiotoxicity, aiding in drug development and personalized treatment strategies.