Publications by authors named "N Du Plessis"
Article Synopsis
- - The development of the ID93+GLA-SE vaccine aims to reduce tuberculosis (TB) recurrence and tackle drug-resistant strains, with plans for a phase 2b efficacy trial for patients in TB treatment.
- - A study using samples from earlier ID93+GLA-SE trials found changes in blood gene expression post-vaccination, including significant immune response indicators at different time points, influenced by dosage and participant sex.
- - Findings highlight the complex interactions in the immune system when responding to the ID93+GLA-SE vaccine and underline the importance of vaccination timing and dosage on effectiveness.
Long-term effect of pneumococcal conjugate vaccines on invasive pneumococcal disease incidence among people of all ages from national, active, laboratory-based surveillance in South Africa, 2005-19: a cohort observational study.
Lancet Glob Health
September 2024
Background: In South Africa, 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in 2009 and 13-valent PCV (PCV13) was introduced in 2011, both in a two plus one schedule. We evaluated the ongoing effects of PCV on the prevention of invasive pneumococcal disease (IPD) over 15 years of sustained surveillance in South Africa before the COVID-19 pandemic.
Methods: We conducted national, active, laboratory-based surveillance for IPD among all ages in South Africa, including isolate serotyping and susceptibility testing.
Tuberculosis (TB) remains a global public health threat. Understanding the dynamics of host-pathogen interactions within TB granulomas will assist in identifying what leads to the successful elimination of infection. In vitro TB models provide a controllable environment to study these granuloma dynamics.
View Article and Find Full Text PDFBackground: Birth HIV point-of-care (POC) tests curtail analytical testing issues and expedite diagnosis, potentially allowing for earlier mother-infant pair engagement and improved outcomes. Many children are lost post antiretroviral therapy (ART) initiation within the first 6 months of follow-up.
Objectives: We compared 6-month retention in care, HIV viral load (VL) suppression and mortality among infants diagnosed with HIV at birth, using laboratory-based versus POC HIV PCR testing.