Research on some metabolic and enzymatic modifications in experimental hypertensive myocardium.

This paper presents our research on metabolic and enzymatic changes in the experimental, Isoproterenol-induced (ISO) hypertensive myocardium of rats. We analyze the effects produced by the simultaneous administration of adenosinetriphosphate (fosfobion) (FOS) and Isoproterenol on the changes in the body weight/heart weight ratio, and on the biochemical changes of cardiac metabolism. We studied the following parameters in the myocardium tissue and blood: plasmatic and tissular creatinin-phosphokinase, Na+K+ ATP-ase in the sarcolemma and the sarcoplasmic reticulum, Ca+2 ATP-ase in the mitochondrial membrane, sarcoplasmic reticulum and sarcolemma, as well as plasmatic and tissular lactate.