In vitro single molecule and bulk phase studies reveal the AP-1 transcription factor cFos binds to DNA without its partner cJun.

The AP-1 transcription factor family crucially regulates progression of the cell cycle, as well as playing roles in proliferation, differentiation, and the stress response. The two best described AP-1 family members, cFos and cJun, are known to dimerize to form a functional AP-1 heterodimer that binds to a consensus response element sequence. Although cJun can also homodimerize and bind to DNA, the canonical view is that cFos cannot bind DNA without heterodimerizing with cJun.

Using numerical modelling in the simulation of mass fish death phenomenon along the Central Coast of Vietnam.

A two-dimensional model was used to reconstruct scenarios related to the mass fish death phenomenon that occurred along the Central Coast of Vietnam. First, a Weather Research Forecasting model was used to simulate the wind field during April 2016, and was then used as an input to the two-dimensional (2D) model. Second, the calibration of the 2D model showed high conformity in both the phases and amplitude between the simulated and observed water levels.

Effectiveness of an individualized multidisciplinary programme for managing unsettled infants.

Objective: To ascertain the effectiveness of an individualized multidisciplinary residential programme for managing young unsettled infants and whether changes in unsettled behaviour were maintained.

Methods: One hundred and nine clients of a Tresillian residential unit with singleton infants aged less than 20 weeks were studied before, during and after intervention. Mothers completed a 24 h infant activity record prior to admission, during the stay and 1 month after discharge.

The scientific study of unusual rapid wound healing: a case report.

This paper examines in a Western medical setting the claim made by a Middle Eastern school of Sufism that its members can attain unusually rapid wound healing from deliberately caused bodily damage. The demonstration involved a Sufi practitioner inserting an unsterilized metal skewer through one side of the cheek area of the face (lateral buccal) and out through the other side. The insertion was observed by Western scientists.