Comparison between Warm-Up Protocols in Post-Activation Potentiation Enhancement (PAPE) of Sprint and Vertical Jump Performance in a Female Futsal Team.

The aim of this study was to examine the influence of three warm-up protocols, with and without post-activation performance enhancement (PAPE), on sprint and vertical jump performance in female athletes. Twenty-five university futsal athletes were randomly assigned to three protocols: i) Traditional Warm-Up (TWU), involving cardiovascular, coordination exercises, and dynamic stretching; ii) Drop Jump Warm-Up (DJWU), consisting of drop jumps from heights of 30 and 40 cm; and iii) Maximum Isometric Warm-Up (MIWU), with high-intensity isometric contractions held for 10 seconds in a squat position at approximately 130-135 degrees of knee flexion. Tests included the countermovement vertical jump (CMVJ) and a 20-meter sprint (S20).

Asymmetric Synthesis of 2-Arylethylamines: A Metal-Free Review of the New Millennium.

2-Arylethylamines are presented in several natural bioactive compounds, as well as in nitrogen-containing drugs. Their ability to surpass the blood-brain barrier makes this family of compounds of especial interest in medicinal chemistry. Asymmetric methodologies towards the synthesis of 2-arylethylamine motives are of great interest due to the challenges they may present.

A comprehensive study of common and rare genetic variants in spermatogenesis-related loci identifies new risk factors for idiopathic severe spermatogenic failure.

Study Question: Can genome-wide genotyping data be analysed using a hypothesis-driven approach to enhance the understanding of the genetic basis of severe spermatogenic failure (SPGF) in male infertility?

Summary Answer: Our findings revealed a significant association between SPGF and the gene and identified three novel genes (, , and ) along with 32 potentially pathogenic rare variants in 30 genes that contribute to this condition.

What Is Known Already: SPGF is a major cause of male infertility, often with an unknown aetiology. SPGF can be due to either multifactorial causes, including both common genetic variants in multiple genes and environmental factors, or highly damaging rare variants.

High-throughput discovery and deep characterization of cyclin-CDK docking motifs.

Cyclin-CDKs are master regulators of cell division. In addition to directly activating the CDK, the cyclin subunit regulates CDK specificity by binding short peptide "docking" motifs in CDK substrates. Here, we measure the relative binding strength of ~100,000 peptides to 11 human cyclins from five cyclin families (D, E, A, B and F).

Ethical considerations for biobanks serving underrepresented populations.

Biobanks are essential biological database resources for the scientific community, enabling research on the molecular, cellular, and genetic basis of human disease. They are crucial for computational, data-driven biomedical research, which advances precision medicine and the development of targeted therapies. However, biobanks often lack racial and ethnic diversity, with many data sets predominantly comprising individuals of white, primarily northern European, ancestry.