Publications by authors named "N Ditzel"
Article Synopsis
- Osteoporosis is a disease that makes bones weaker as people get older, increasing the risk of fractures.
- Scientists found two plant-based antioxidants, Apigenin and Rutaecarpine, that help bone stem cells grow into bone cells better.
- These antioxidants could help maintain healthy bones as we age and might be a way to prevent osteoporosis.
Obesity and type 2 diabetes (T2D) are growing health challenges with unmet treatment needs. Traf2- and NCK-interacting protein kinase (TNIK) is a recently identified obesity- and T2D-associated gene with unknown functions. We show that TNIK governs lipid and glucose homeostasis in and mice.
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- Scientists discovered a substance called KIAA1199 that affects how stem cells in the bone help the bone to grow and heal.
- High levels of KIAA1199 in the blood can mean a higher chance of breaking bones, especially in older people with weak bones.
- Removing KIAA1199 from stem cells made them better at forming new bone, leading to stronger bones and faster healing in experiments with mice.
The development of novel biomaterials for regenerative therapy relies on the ability to assess tissue development, quality, and similarity with native tissue types in experiments. Non-invasive imaging modalities such as X-ray computed tomography offer high spatial resolution but limited biochemical information while histology and biochemical assays are destructive. Raman spectroscopy is a non-invasive, label-free and non-destructive technique widely applied for biochemical characterization.
View Article and Find Full Text PDFCurrent techniques for monitoring disease progression and testing drug efficacy in animal models of inflammatory arthritis are either destructive, time-consuming, subjective, or require ionizing radiation. To accommodate this, we have developed a non-invasive and label-free optical system based on Raman spectroscopy for monitoring tissue alterations in rodent models of arthritis at the biomolecular level. To test different sampling geometries, the system was designed to collect both transmission and reflection mode spectra.
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