Publications by authors named "N Disotuar Ruiz"
Two-component signal transduction systems (TCSs) are nearly ubiquitous across bacterial species and enable bacteria to sense and respond to specific cues for environmental adaptation. The BumSR TCS is unusual in that the BumS sensor exclusively functions as a phosphatase rather than a kinase to control phosphorylated levels of its cognate BumR response regulator (P-BumR). We previously found that BumSR directs a response to the short-chain fatty acid butyrate generated by resident microbiota so that identifies ideal lower intestinal niches in avian and human hosts for colonization.
View Article and Find Full Text PDFThis study investigated the impact of an oxygen-rich spray on rainbow trout subjected to short-term air exposure episodes. These episodes can be due to sampling procedures or catch-and-release (C&R) practices, focusing on behavioral, haematological, and physiological responses. For this, 12 rainbow trout were divided into two groups: control and oxygen-rich sprayed fish.
View Article and Find Full Text PDFArticle Synopsis
- The study highlights how underrepresentation in clinical genomics research diminishes the relevance of findings and benefits, particularly emphasizing the importance of diverse participant inclusion.
- Researchers implemented patient-centered, data-driven strategies, such as using relatable and flexible recruitment methods, to ensure a diverse sample of parents and children in a pediatric genome sequencing study.
- As a result, a high percentage of eligible participants agreed to enroll (93.5% acceptance) and the majority of those who enrolled completed the study, demonstrating the effectiveness of engaging with underrepresented communities.
Colorectal liver metastases grow following different histologic growth patterns (HGPs), classified as desmoplastic and nondesmoplastic (dHGP, non-dHGP), being the latter associated with worst prognosis. This study aimed to investigate the tumor microenvironment (TME) between HGPs supporting different survival. Multiplexed immunohistochemical staining was performed with the Opal7 system in a 100-patients cohort to evaluate the tumor-liver interface with three different cell panels: lymphoid, myeloid, and carcinoma-associated fibroblasts.
View Article and Find Full Text PDFBackground: The demand for aesthetic treatments targeting the middle and lower face is on the rise, especially because of changes in appearance associated with aging.
Aim: This study aimed to assess the use of a hybrid filler for sculpting and contouring of the chin, jaw, and malar region.
Methods And Materials: A retrospective analysis was performed on patients who underwent jaw and chin contouring and cheek augmentation using a hybrid filler (hyaluronic acid and dextranomer).