Publications by authors named "N Direk"
Introduction: Cardiovascular risk in depression has been investigated in small clinical samples and population-based studies revealing inconclusive results. However, cardiovascular risk in drug-naive depressed patients has not been tested extensively.
Methods: Body mass index-based Framingham Cardiovascular Risk Scores and soluble intercellular adhesion molecule-1 (sICAM-1) levels were used to assess the risk of cardiovascular disease in drug-naive depressed patients and healthy volunteers.
Article Synopsis
- A rise in trans adolescents seeking medical interventions for gender dysphoria (GD) has been noted, prompting a study on clinical features, treatment, and follow-up of these individuals.
- Between 2016 and 2022, 53 adolescents (26 male-to-female and 27 female-to-male) were reviewed, revealing a median age of around 16 years at referral and puberty blockade.
- Treatments such as hormone therapy were generally well-received, effective, and transition clinics proved essential for managing gender reassignment processes.
Introduction: Even though the effect of inflammation on pathogenesis of obsessive compulsive disorder (OCD) is known, information regarding the underlying mechanisms are yet to be revealed. The NLRP3 inflammasome complex is an important component of the innate immune system that initiates and mediates inflammatory response to a variety of stimuli. This study aims to inquire into a possible association between NLRP3 inflammasome complex and OCD.
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- Cerebrovascular disease may contribute to late-life depression, but existing evidence linking neuroimaging indicators with depressive symptoms is mixed. This study analyzed a large group of middle-aged and elderly individuals over time to clarify these connections.
- In a population of 4943 participants, findings revealed that smaller total brain volume, larger white matter hyperintensities, and the presence of cortical infarcts were associated with higher depressive symptoms at both initial assessments and over time.
- The study concluded that damage to white matter structures significantly correlated with increasing depressive symptoms, especially among older adults, highlighting the importance of brain health in mental well-being as people age.