Publications by authors named "N Diez-Padrisa"
Article Synopsis
- - The RTS,S/AS01 vaccine showed moderate effectiveness against malaria in African infants and children, prompting researchers to investigate how the immune system responds to the vaccination.
- - Using a unique blood transcriptional module framework, the study analyzed immune responses before and after vaccination, revealing significant changes in T-cell activation but fewer indications that these changes directly impacted malaria risk.
- - The findings suggest that certain immune markers present before vaccination are linked to malaria risk, indicating potential roles for specific immune cell types in either promoting or inhibiting vaccine protection.
The RTS,S/AS01 vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 clinical trial using a 3-dose immunization schedule. A fourth-dose 18 months after the primary vaccination was shown to restore the waning efficacy. However, only total IgG against the immunodominant malaria vaccine epitope has been analyzed following the booster.
View Article and Find Full Text PDFBackground: Vaccination and naturally acquired immunity against microbial pathogens may have complex interactions that influence disease outcomes. To date, only vaccine-specific immune responses have routinely been investigated in malaria vaccine trials conducted in endemic areas. We hypothesized that RTS,S/A01E immunization affects acquisition of antibodies to Plasmodium falciparum antigens not included in the vaccine and that such responses have an impact on overall malaria protective immunity.
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