Publications by authors named "N Diazgranados"
Purpose: Stressful life events are associated with problematic drinking, and alcohol misuse has been exacerbated during the coronavirus disease 2019 (COVID-19) pandemic. While coping motives may account for this association, positive life events (PLEs) and enhancement motives are understudied. To address these gaps, we examined the associations of history of alcohol use disorder (AUD), negative life events (NLEs), and PLEs with problematic alcohol use and tested coping and enhancement motives as mediators.
View Article and Find Full Text PDFDynamics of Splenic Transient Elastography in Patients With Alcohol Use Disorder.
Clin Transl Gastroenterol
November 2024
Introduction: Splenic stiffness (SS) measurement (SSM) is an evolving noninvasive assessment to evaluate portal hypertension. Studies with respect to SSM in patients with alcohol use disorder are limited.
Methods: We studied patients seeking treatment for alcohol use disorder in an inpatient treatment protocol at the National Institutes of Health and parsed SSM into 3 groups based on degree of change.
Smoking-Related Increases in Alcohol Outcomes and Preliminary Evidence for the Protective Effect of a Functional Nicotine Receptor Gene (CHRNA5) Variant on Alcohol Consumption in Individuals Without Alcohol Use Disorder.
Int J Neuropsychopharmacol
October 2024
Article Synopsis
- Alcohol and nicotine interact with the nicotinic acetylcholine receptor system, influencing reward responses and leading to increased co-use and misuse of these substances.
- A specific genetic variation (rs16969968) in the CHRNA5 gene is strongly linked to nicotine effects, but its role in alcohol consumption is less understood.
- In a study with 980 participants, smokers reported higher alcohol use, and those with the GG genotype consumed more alcohol than those with the AA/AG genotypes, suggesting that this genetic variant may partly protect against alcohol misuse by influencing negative expectations about drinking.
Background And Aims: Alcohol-associated hepatitis (AH) is a clinically severe, acute disease that afflicts only a fraction of patients with alcohol use disorder. Genomic studies of alcohol-associated cirrhosis (AC) have identified several genes of large effect, but the genetic and environmental factors that lead to AH and AC, and their degree of genetic overlap, remain largely unknown. This study aims to identify genes and genetic variations that contribute to the development of AH.
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