Promoting resilience in adults with experience of intimate partner violence or child maltreatment: a narrative synthesis of evidence across settings.

Background: People who have experienced intimate partner violence (IPV) or child maltreatment (CM) are at risk of having lower resilience and adverse psychological outcomes. In keeping with the social and environmental factors that support resilience, there is a need to take a public health approach to its investigation and to identify existing initiatives in particular settings and populations that can guide its deliberate promotion.

Method: This narrative synthesis examines quantitative and qualitative studies of interventions with resilience-related outcomes in specified health and other settings.

Cognitive behavioral therapy age effects in child and adolescent anxiety: an individual patient data metaanalysis.

Background: Investigations of age effects on youth anxiety outcomes in randomized trials (RCTs) of cognitive behavior therapy (CBT) have failed to yield a clear result due to inadequate statistical power and methodologic weaknesses. We conducted an individual patient data metaanalysis to address this gap.

Question: Does age moderate CBT effect size, measured by a clinically and statistically significant interaction between age and CBT exposure?

Methods: All English language RCTs of CBT for anxiety in 6-19 year olds were identified using systematic review methods.

Randomized trials published in higher vs. lower impact journals differ in design, conduct, and analysis.

Objective: To compare methodological characteristics of randomized controlled trials (RCTs) published in higher vs. lower impact Core Clinical Journals.

Study Design And Setting: We searched MEDLINE for RCTs published in 2007 in Core Clinical Journals.

A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder.

Converging lines of evidence suggest that the glutamatergic system may play an increasingly important role in the development of novel therapeutics for major depressive disorder (MDD), particularly agents associated with rapid antidepressant effects. Diverse glutamatergic modulators targeting N-methyl-D-aspartate receptors have shown efficacy in MDD, but their associated psychotomimetic effects presently preclude their use in larger samples. This small, randomized, double-blind, placebo-controlled, crossover pilot study evaluated the potential antidepressant efficacy and tolerability of an oral formulation of the selective N-methyl-D-aspartate NR2B antagonist MK-0657 in patients with treatment-resistant MDD (TRD).

Credibility of claims of subgroup effects in randomised controlled trials: systematic review.

Objective: To investigate the credibility of authors' claims of subgroup effects using a representative sample of recently published randomised controlled trials.

Design: Systematic review.

Data Source: Core clinical journals, as defined by the National Library of Medicine, in Medline.