Publications by authors named "N Dia"
Article Synopsis
- Acinetobacter baumannii, especially the carbapenem-resistant strains (CRAB), is a critical pathogen linked to antimicrobial resistance (AMR) and is prioritized by the WHO.
- Phage therapy is being explored as a potential treatment for CRAB infections due to increasing resistance to conventional antibiotics.
- A newly isolated lytic phage, vAbaIN10, exhibits effective lytic activity against CRAB in various conditions and shows promise in advancing treatment options for multidrug-resistant infections.
Background: In adult patients with sepsis or septic shock admitted to the emergency department, a single intravenous 15 mg/kg amikacin dose provides inadequate pharmacokinetic-pharmacodynamic target attainment at the locally reported minimum inhibitory concentration (MIC) of 2 mg/L and the European Committee on Antimicrobial Susceptibility Testing clinical breakpoint for Enterobacterales of 8 mg/L.
Objectives: To provide an amikacin dosing strategy with a clinically acceptable probability of target attainment (PTA) for all patients.
Methods: Stochastic simulations were performed using a two-compartment population pharmacokinetics model of amikacin (NONMEM 7.
Recent Molecular Epidemiology of Echovirus 11 Throughout North and West Africa Resulted in the First Identification of a Recombinant Strain from an Acute Flaccid Paralysis Case in West Africa.
Viruses
November 2024
Article Synopsis
- Echovirus 11 is causing increasing cases of neonatal sepsis in Europe and limited reports in West Africa, highlighting a significant public health issue.
- A study analyzed 23 E11 strains from West Africa using high-throughput sequencing, marking the first molecular characterization of the virus in the region and revealing a new recombinant strain.
- The research indicates that E11 has evolved into four distinct clades since the 1970s, with instances of the virus spreading from West Africa to Europe, underscoring the need for enhanced surveillance of enteroviruses in Africa.
Outbreak of severe acute respiratory infections caused by recombinant human adenovirus type B 7/3 in hospitalized infants from a nursery in Dakar, April 2024.
IJID Reg
December 2024
Objectives: Acute respiratory infections are among the leading cause of mortality in children under 5 years of age worldwide, with most of these deaths due to bronchiolitis and pneumonia. We investigated and analyzed a pediatric outbreak of acute respiratory infections that resulted in the hospitalization of four infants in a nursery in Dakar in late April 2024.
Methods: Nasopharyngeal specimens were collected from infants and tested for a panel of respiratory pathogens by multiplex real-time reverse transcription-polymerase chain reaction.
Article Synopsis
- * In this study, two bacteriophages, vAbBal23 and vAbAbd25, were isolated from wastewater in Dakar, Senegal, and extensively characterized for their effectiveness against extremely drug-resistant strains of A. baumannii.
- * Both phages showed strong antibacterial properties across various pH levels and temperatures, with the ability to attack both active and biofilm forms of the bacteria, indicating their potential as safe therapeutic agents devoid of harmful genes.