Publications by authors named "N Di Muzio"
Training and temporally validating an NTCP model of acute toxicity after whole breast radiotherapy, including the impact of advanced delivery techniques.
Radiother Oncol
December 2024
Purpose: The aim is to train and validate a multivariable Normal Tissue Complication Probability (NTCP) model predicting acute skin reactions in patients with breast cancer receiving adjuvant Radiotherapy (RT).
Methods And Materials: We retrospectively reviewed 1570 single-institute patients with breast cancer treated with whole breast irradiation (40 Gy/15fr). The patients were divided into training (n = 878, treated with 3d-CRT, from 2009 to 2017) and validation cohorts (n = 692, treated from 2017 to 2021, including advanced RT techniques).
Introduction: Chemoradiotherapy in head and neck cancer patients has a curative intent but often deteriorates nutritional status leading to sarcopenia and cachexia.
Methods: In this observational and single-centered study, a prospective evaluation of several biochemical and anthropometrical parameters, weight loss, handgrip strength, visual analogue scale of appetite, questionnaires associated with malnutrition & quality of life and body composition (obtained by Bioelectrical Impedance Vector Analysis) was performed before and after high-dose cisplatin chemotherapy combined with radiotherapy in 60 patients affected by head and neck cancer. Oral nutritional supplements were used to reach the correct number of daily calories and proteins.
Article Synopsis
- * The study presents a case of a 42-year-old woman with HER-2 positive primary ductal adenocarcinoma, detailing her treatment journey, which included surgery, radiotherapy, chemotherapy, and targeted therapy, leading to a favorable outcome.
- * The report highlights the importance of early diagnosis and a multimodal treatment approach for such aggressive tumors, emphasizing the need for documenting individual cases to improve patient management.
Article Synopsis
- - Oropharyngeal cancer (OphC) during pregnancy is rare but may become more common, and delays in treatment can negatively impact survival; current data on radiation therapy's effects on pregnant patients and their children are limited.
- - A case study describes a 39-year-old pregnant woman with advanced OphC who received surgery and radiation therapy, using techniques to minimize fetal radiation exposure, with an estimated dose of about 50 mSv.
- - The patient remained cancer-free after 10 years, and her daughter, born at nearly 34 weeks, is healthy and performing well in school, suggesting that optimizing radiation treatment during pregnancy can protect both mother and child.