Publications by authors named "N Dhir"
Article Synopsis
- Valproic acid (VPA) is commonly used to create preclinical models for autism spectrum disorder (ASD) but also leads to adverse effects in offspring, including physical malformations and changes in maternal behavior.
- This study focused on how VPA impacts pregnant Wistar rats, finding that VPA-treated females exhibited reduced litter sizes, increased instances of cannibalism, and higher miscarriage rates compared to control groups.
- The results underscore VPA's significant teratogenic effects and disruptions in maternal behavior, highlighting potential mechanisms behind these changes in the context of ASD research.
The Catalogue Of Somatic Mutations In Cancer (COSMIC), https://cancer.sanger.ac.
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- Autism Spectrum Disorder (ASD) is a complex condition, and current animal models like Valproic Acid (VPA) and Propionic Acid (PPA) were found to be inadequate in mimicking the human disease fully.
- The study tested several chemically induced animal models (including Poly I:C and Dioxin) to identify which best reflects the clinical features of ASD, with the Poly I:C model showing the closest resemblance.
- Findings indicated significant behavioral and developmental changes, increased oxidative stress, and altered gene expression related to ASD in the model groups, highlighting the role of maternal immune activation in influencing embryonic development and contributing to ASD.
Background: Stroke, a devastating neurological emergency, is the leading cause of worldwide mortality and functional disability. Combining novel neuroprotective drugs offers a way to improve the stroke intervention outcomes. In the present era, the combination therapy has been proposed as a plausible strategy to target multiple mechanisms and enhance the treatment efficacy to rescue stroke induced behavioral abnormalities and neuropathological damage.
View Article and Find Full Text PDFMechanical circulatory support for thyrotoxicosis-induced cardiomyopathy.
Proc (Bayl Univ Med Cent)
November 2022
Thyroid storm is a life-threatening condition which, in rare cases, may lead to cardiogenic shock and dysrhythmias. Mechanical circulatory support with an Impella device or extracorporeal membrane oxygenation may be used as a bridge to recovery in these cases. This case involves a patient with thyrotoxicosis and reduced ejection fraction and hemodynamic instability requiring Impella device placement.
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