Publications by authors named "N Denko"
Hypoxia is a common feature of solid tumors that has previously been linked to resistance to radiotherapy and chemotherapy, and more recently to immunotherapy. In particular, hypoxic tumors exclude T cells and inhibit their activity, suggesting that tumor cells acquire a mechanism to evade T-cell recognition and killing. Our analysis of hypoxic tumors indicates that hypoxia downregulates the expression of MHC class I and its bound peptides (i.
View Article and Find Full Text PDFUnlabelled: Emerging evidence supports the important role of the tumor microbiome in oncogenesis, cancer immune phenotype, cancer progression, and treatment outcomes in many malignancies. In this study, we investigated the metastatic melanoma tumor microbiome and its potential roles in association with clinical outcomes, such as survival, in patients with metastatic disease treated with immune checkpoint inhibitors (ICI). Baseline tumor samples were collected from 71 patients with metastatic melanoma before treatment with ICIs.
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- Tumor hypoxia makes it harder for radiation therapy to work effectively, which can lead to worse outcomes for cancer patients.
- Researchers studied how low oxygen levels in tumors might affect the microbes living inside them in patients with colorectal cancer.
- They found that certain microbes in hypoxic tumors can predict poor patient outcomes, suggesting that the relationship between low oxygen, microbes, and radiation impacts treatment success.
Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival.
Cancer Biol Ther
December 2024
Article Synopsis
- Head and Neck Squamous Cell Carcinoma (HNSCC) is a complex group of tumors influenced by the tumor microenvironment (TME), which includes microorganisms and immune cells, affecting treatment response and survival rates.
- Researchers analyzed RNA sequencing data from The Cancer Genome Atlas (TCGA) to link specific microbes and gene expression patterns to overall survival (OS), finding that the presence of the Alphapapillomavirus 9 virus was associated with better survival outcomes.
- The study revealed that HPV-negative tumors had a higher presence of certain harmful microbes and macrophages linked to tumor progression, suggesting the TME's potential role in predicting patient outcomes and understanding resistance to therapies.