Publications by authors named "N Delaleu"
Cancer is highly infiltrated by myeloid-derived suppressor cells (MDSCs). Currently available immunotherapies do not completely eradicate MDSCs. Through a genome-wide analysis of the translatome of prostate cancers driven by different genetic alterations, we demonstrate that prostate cancer rewires its secretome at the translational level to recruit MDSCs.
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- - Fabry disease is a rare genetic disorder linked to the alpha-galactosidase gene, and while it can be managed with enzyme replacement therapy (ERT), understanding FN's molecular roots is essential for identifying biomarkers and drug targets.
- - The study involved RNA sequencing of biopsies from two cohorts of Fabry nephropathy patients and control individuals, revealing significant differences in gene expression associated with the disease and its response to ERT over time.
- - Despite some positive responses to early ERT—especially in gene expression patterns—many biological pathways, particularly in glomeruli and arteries, remained altered, leading to the identification of 69 potential drug repurposing candidates as adjunct treatments.
Autoimmune polyendocrine syndrome type I (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene and characterised clinically by multiple autoimmune manifestations and serologically by autoantibodies against tissue proteins and cytokines. We here hypothesised that lack of AIRE expression in thymus affects blood immune cells and performed whole-blood microarray analysis (N = 16 APS-I patients vs 16 controls), qPCR verification, and bioinformatic deconvolution of cell subsets. We identified B cell responses as being downregulated in APS-1 patients, which was confirmed by qPCR; these results call for further studies on B cells in this disorder.
View Article and Find Full Text PDFMinimal change disease (MCD), a major cause of nephrotic syndrome, is usually treated by corticosteroid administration. MCD unresponsiveness to therapy and recurrences are nonetheless frequently observed, particularly in adults. To explore MCD-related pathogenetic mechanisms and to identify novel drug targets ultimately contributing to novel therapeutic avenues with a certain specificity for MCD, we compared glomerular transcriptomes from MCD with membranous nephropathy (MN) patients and healthy controls.
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- * Researchers separated human memory T lymphocytes based on their inflammatory cytokine production to identify factors influencing pathogenic T cell behavior.
- * They discovered that a specific gene signature and the activation of the NF-κB pathway, along with the repressor BHLHE40, regulate the proinflammatory characteristics of these T cells, potentially linking it to diseases.