Characterization of Antioxidant Bioactive Compounds and Rheological, Color and Sensory Properties in 3D-Printed Fruit Snacks.

The influence of wheat starch (6%, 8% and 10%, /) and a 3D printing program (program 1 vs. program 2) on the content of bioactive compounds, antioxidant capacity, color parameters and rheological and sensory properties was investigated in 3D strawberry and strawberry tree fruit snacks. Increasing the starch content led to a decrease in the content of almost all the bioactive compounds, while it had no effect on the antioxidant capacity.

The Modulation Effect of a Fermented Bee Pollen Postbiotic on Cardiovascular Microbiota and Therapeutic Perspectives.

Hypertension is a frequent comorbidity in patients with heart failure; therefore, blood pressure management for these patients is widely recommended in medical guidelines. Bee pollen and postbiotics that contain inactivated probiotic cells and their metabolites have emerged as promising bioactive compounds sources, and their potential role in mitigating cardiovascular (CV) risks is currently being unveiled. Therefore, this preliminary study aimed to investigate the impact of a lactic-fermented bee pollen postbiotic (FBPP) on the CV microbiota via in vitro tests.

Mathematical Modeling and Software Tools for Breeding Value Estimation Based on Phenotypic, Pedigree and Genomic Information of Holstein Friesian Cattle in Serbia.

In this paper, six univariate and two multivariate best linear unbiased prediction (BLUP) models were tested for the estimation of breeding values (BV) in Holstein Friesian cattle in Serbia. Two univariate models were formed using the numerator relationship matrix (NRM), four using the genomic relationship matrix (GRM). Multivariate models contained only an NRM.

Upregulation of Tolerogenic Pathways by the Hydrogen Sulfide Donor GYY4137 and Impaired Expression of HS-Producing Enzymes in Multiple Sclerosis.

The aim of this study was to examine the in vitro effects of the slow-releasing HS donor GYY4137 on the immune cells involved in the pathogenesis of the central nervous system (CNS) autoimmune disease, multiple sclerosis (MS). GYY4137 specifically potentiated TGF-β expression and production in dendritic cells and significantly reduced IFN-γ and IL-17 production in the lymph node and spinal cord T cells obtained from mice immunized with CNS antigens. Both the proportion of FoxP3 regulatory CD4 T cells in the lymph node cells, and the percentage of IL-17 CD4 T cells in the spinal cord cells were reduced upon culturing with GYY4137.

Isolation and enrichment of mouse insulin-specific CD4 T regulatory cells.

Polyclonal T regulatory cells (Treg - CD4CD25CD127Foxp3) are used in several protocols for the treatment of type 1 diabetes (T1D), multiple sclerosis and graft-versus host disease in clinical trials. However, general opinion is that autoantigen-specific Treg could be more efficient in autoimmunity suppression due to their direct effect on pathogenic autoantigen-specific effector T cells. This study describes isolation and expansion of insulin-specific Treg in vitro.