Publications by authors named "N Dalvi"
Background: Many oral and maxillofacial surgery patients are young, healthy adults who are opioid-naïve. Over-prescribing opioids increases the risk of subsequent misuse and diversion.
Purpose: The purpose of this study was to measure and compare opioid prescriptions to opioid naïve and nonnaïve patients by oral and maxillofacial surgeons in Massachusetts from 2012 to 2022.
Purpose: Pharmacologic therapies for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PNs) are limited; currently, none are US Food and Drug Administration-approved for adults.
Methods: ReNeu is an open-label, multicenter, pivotal, phase IIb trial of mirdametinib in 58 adults (≥18 years of age) and 56 children (2 to 17 years of age) with NF1-PN causing significant morbidities. Patients received mirdametinib capsules or tablets for oral suspension (2 mg/m twice daily, maximum 4 mg twice daily), regardless of food intake, in 3 weeks on/1 week off 28-day cycles.
Article Synopsis
- Hemophagocytic lymphohistiocytosis (HLH) is a rare immune disorder, and this case presents a unique instance of it affecting the central nervous system (CNS) in a pediatric patient.
- A 15-year-old boy exhibited symptoms like ataxia and MRI findings of multiple brain hemorrhages, which led to a confirmed diagnosis of familial CNS-HLH through genetic testing.
- After failing initial treatments, he underwent stem cell transplantation and showed significant improvement, underlining the importance of considering CNS-HLH in similar cases to avoid delays in diagnosis and treatment.
This study focuses on the design concepts that contribute to the C-H activation in bithiophene-flanked monomers incorporating naphthalene diimide (NDI), perylene diimide (PDI), and fluorene (FLU) and their polymerization by direct heteroarylation. Density functional theory (DFT) calculations reveal distinct energy requirements for C-H bond abstraction, which is dictated by the electron-withdrawing strength of the central aromatic core flanked by bithiophene. These provide insights into the reactivity of each monomer for C-H bond activation.
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- Neuropsychological studies indicate that anxiety and depression symptoms are common in patients with lifestyle disorders, but their effects on movement are not well understood.
- This study explores how high fat diet, chronodisruption, and their combination impact locomotor function by examining changes in cerebellar gene expression and signaling pathways.
- Results show significant deficits in locomotor ability across all experimental groups, along with notable inflammation and damage to Purkinje cells in the cerebellum, highlighting the relationship between cerebellar function, movement, and certain genetic pathways.