Publications by authors named "N Dalbeth"
Relationship between gout flare states and patient-reported outcomes following allopurinol initiation.
Arthritis Care Res (Hoboken)
January 2025
Article Synopsis
- Gout flares are crucial indicators of the disease's impact, with specific maximum flare counts linked to acceptable symptom states (PASS) and low disease activity (LDA).
- A study analyzed data from 179 gout patients over 12 months, focusing on flare occurrences and assessing their impact on patient-reported outcomes, including quality of life and illness perception.
- Results showed that while many participants achieved either PASS or LDA, increased flare frequency correlated with higher negative impacts on patients, emphasizing the need for effective flare prevention strategies in gout management.
Background: Patients' negative expectations about medication can exacerbate side effect burden leading to low adherence and persistence. A novel intervention involves targeting mindsets about non-severe symptoms; reframing them as encouraging signs of medication working.
Purpose: This study aimed to assess whether a brief symptom-mindset intervention can improve symptom experience and adherence in patients starting methotrexate to treat an inflammatory rheumatic disease.
Gout flares after stopping anti-inflammatory prophylaxis: a rapid literature review and meta-analysis.
Arthritis Care Res (Hoboken)
December 2024
Objective: The aim of this research was to determine how common gout flares are after ceasing anti-inflammatory prophylaxis.
Methods: A rapid literature review and meta-analysis were undertaken. PubMed was searched from inception to February 2024.
Importance: Clinicians often approach urate-lowering therapy (ULT) cautiously in patients with gout and impaired kidney function because they are concerned about the risk of progression to severe or end-stage kidney disease. However, evidence from randomized clinical trials of this association remains inconclusive.
Objective: To evaluate the association between achieving target serum urate level with ULT and progression of chronic kidney disease (CKD) to severe or end-stage in patients with gout and impaired kidney function.
Objective: Evidence for an association of smoking with gout is conflicting. We assessed associations of current and past smoking with gout in an Aotearoa New Zealand (NZ) population.
Methods: Multivariable logistic regression analysis was performed on cross-sectional data from participants of NZ Māori (from 2 studies: Genetics of Gout in Aotearoa [GGA] study of 293 participants with gout and 431 without; and Ngāti Porou Hauora [NPH] study of 111 participants with gout and 42 without), Pacific people (257 participants with gout and 357 without), and European (694 participants with gout and 688 without) ancestry.