Publications by authors named "N D Toussaint"
Aim: There is limited evidence to support the use of oral anticoagulation (OAC) in people with advanced chronic kidney disease (CKD) and atrial fibrillation (AF). The aim of this study is to characterise the practice patterns and priorities of clinicians in the management of non-valvular AF and primary prevention of AF-related stroke in people with stage 4-5D CKD.
Methods: This was an annonymous, multiple-choice, electronic survey distributed to and undertaken by nephrology and cardiology clinicians in Australia and New Zealand.
Article Synopsis
- Deep single-cell multi-omic profiling is an innovative method to study drug resistance in relapsed or refractory acute myeloid leukemia (AML).
- The research combines various single-cell analyses and clinical data from 21 patients, revealing that treatment with both a hypomethylating agent and the Bcl-2 inhibitor venetoclax leads to reduced drug responsiveness compared to other treatment sequences.
- The study identifies both known and new resistance mechanisms, suggesting alternative therapies like the PLK inhibitor volasertib and highlighting the potential of targeting CD36 in treatment-resistant AML blasts.
Background And Aims: Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD) and has been associated with abnormalities of mineral metabolism and vascular calcification. Vitamin D influences parathyroid hormone values and calcium and phosphate metabolism, and may play a role in vascular function and bone health. We aimed to test our hypothesis that vitamin D deficiency is associated with arterial stiffness, aortic calcification and lower bone mineral density (BMD) in patients with CKD.
View Article and Find Full Text PDFIn people with chronic kidney disease (CKD), the physiology of vitamin D is altered and leads to abnormalities in bone and mineral metabolism which contribute to CKD mineral and bone disorder (CKD-MBD). Observational studies show an association between vitamin D deficiency and increased risk of mortality, cardiovascular disease and fracture in CKD. Although vitamin D therapy is widely prescribed in people with CKD, clinical trials to date have failed to demonstrate a clear benefit of either nutritional vitamin D supplementation or active vitamin D therapy in improving clinical outcomes in CKD.
View Article and Find Full Text PDFBackground: Disparities in aspects of chronic kidney disease progression and management exist for patients from culturally and linguistically diverse (CALD) backgrounds, including with treatment and outcomes for kidney transplantation.
Objective: This study aimed to explore factors that impact kidney transplant outcomes from the perspective of kidney transplant recipients (KTRs) from CALD backgrounds and their family caregivers.
Methods: A descriptive qualitative design was utilised.