Publications by authors named "N D Ritchie"
Article Synopsis
- The study evaluates the accuracy of electron-excited X-ray microanalysis using energy-dispersive spectrometry (EDS) at a low beam energy of 5 keV, suitable for analyzing almost all elements on the periodic table, except hydrogen and helium.
- Elemental analysis was performed on various certified reference materials, stoichiometric compounds, minerals, and metal alloys, totaling 263 measurements across 39 elements in 113 materials.
- Results showed high accuracy, with over 98% of measurements within ±5% relative deviation from expected values, and 82% falling within a tighter range of -2% to 2% relative deviation.
Article Synopsis
- Bacterial pathogens need to bypass host immune defenses and nutrient limitations to cause infections, making the use of human serum a promising medium for discovering new antibacterial drugs.
- A recent high-throughput screen using human serum revealed compounds that not only inhibited bacterial growth but also enhanced it, particularly synthetic siderophores that help bacteria acquire iron.
- The most effective compound, a synthetic siderophore combined with the antibiotic aztreonam, led to the creation of MLEB-22043, a broad-spectrum antibiotic that shows improved efficacy against resistant bacteria when paired with a β-lactamase inhibitor.
The increasing prevalence of antibiotic resistance demands the discovery of antibacterial chemical scaffolds with unique mechanisms of action. Phenotypic screening approaches, such as the use of reporters for bacterial cell stress, offer promise to identify compounds while providing strong hypotheses for follow-on mechanism of action studies. From a collection of ∼1,800 GFP transcriptional reporter strains, we identified a reporter that is highly induced by cell envelope stress-pProm -GFP.
View Article and Find Full Text PDFBackground: The National Diabetes Prevention Program (National DPP) is an evidence-based lifestyle intervention successfully disseminated across the United States. Some adaptations have been made to address real-world needs, including during the COVID-19 pandemic. This study aims to qualitatively describe adaptations Lifestyle Coaches made in response to the pandemic.
View Article and Find Full Text PDFBackground: Diabetes self-management education and support can be effectively and efficiently delivered in primary care in the form of shared medical appointments (SMAs). Comparative effectiveness of SMA delivery features such as topic choice, multi-disciplinary care teams, and peer mentor involvement is not known.
Objective: To compare effects of standardized and patient-driven models of diabetes SMAs on patient-level diabetes outcomes.